Protein crystallization in lipid cubic phase
- Event time: 1:00pm
- Event date: 17th February 2003
- Speaker: Shinpei Tanaka (University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Lipid cubic phase is a cell structure in which a whole volume is divided into nanometer-sized cells by membranes, connected by water channels. The size of a protein molecule on the other hand, is in general a few nanometer. Therefore, when proteins are forced to sit in the cubic phase, it is expected that there is a strong interaction between membranes and protein molecules, which affects the phase behavior of protein solutions. In this talk, I will introduce my recent results for the mixture of protein (lysozyme) solutions and lipids (monoolein). The phase diagram of the protein solutions are significantly altered in the presence of cubic phase structure. Some basic ideas to explain it will be discussed.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..