Computer models for DNA organisation: bacteriophages and the human nucleus
Computer models for DNA organisation: bacteriophages and the human nucleus
- Event time: 1:00pm
- Event date: 29th March 2010
- Speaker: Professor Davide Marenduzzo (School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
I will present some computer simulation studies of the organisation of DNA in confined geometries. Firstly, I will discuss the case of bacteriophages, the viruses of bacteria. There, DNA is packed up to almost crystalline density. In order to understand the experimental observations on DNA structure and knot spectrum, I will show that it is necessary to carefully think about DNA:DNA interactions in a crowded environment. Secondly, I will present a polymer model of chromosomes, which takes into account the variations in (transcriptional) activity and predicts a spatial patterning which is close to the one observed in reality.
About Condensed Matter lunchtime seminars
This is a weekly series of informal talks given primarily by members of the institute of condensed matter and complex systems, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..