Computer models for DNA organisation: bacteriophages and the human nucleus
I will present some computer simulation studies of the organisation of DNA in confined geometries. Firstly, I will discuss the case of bacteriophages, the viruses of bacteria. There, DNA is packed up to almost crystalline density. In order to understand the experimental observations on DNA structure and knot spectrum, I will show that it is necessary to carefully think about DNA:DNA interactions in a crowded environment. Secondly, I will present a polymer model of chromosomes, which takes into account the variations in (transcriptional) activity and predicts a spatial patterning which is close to the one observed in reality.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..