Multicellular organisms posses a wide-range of antimicrobial peptides (AMPs) which act as natural barrier to bacteria. As more bacteria become resistant to the antibiotics that are used heavily today, the development of AMPs as a new class of antibiotics has become a realistic possibility. In order to compare the relative strengths of antibiotic agents Minimum Inhibitory Concentration (MIC) assays are used. I will discuss MIC measurements of Pexiganan on Escherichia coli and show the resulting growth curves at sub-inhibitory concentrations. It was found that the peptide caused cell lag time to lengthen as well as some cell death at these concentrations.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..