Elucidating the locking mechanism of peptides onto growing amyloid fibrils
Amyloid fibrils are highly ordered protein or polypeptide assemblies that are best known in connection with neurodegenerative diseases although more recently a number of naturally occurring fibril-forming proteins with functional rather than disease-related properties have been discovered. In addition, such peptides may be attractive building blocks for self-assembling nanomaterials. We studied the dynamical mechanism of addition of a heptapeptide to a growing fibril though molecular simulations.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..