Competition for space in growing bacterial populations: what determines the winners and losers?
- Event time: 1:00pm
- Event date: 19th November 2012
- Speaker: Diarmuid Lloyd (Formerly School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
In the natural environment, bacterial populations often form densely packed self-assembled structures in cavities or on surfaces. Understanding how cells compete for space in these communities is essential if we are to translate our understanding of population dynamics and evolution in well-mixed communities to these real-life situations. We have used fluorescence microscopy to study the competition for space between thousands of bacterial cells as they colonize a two-dimensional agarose surface. For each individual progenitor cell, we quantify the likelihood that their descendants will out-perform their neighbours for local space under a range of environmental conditions, and how this affects the patterns of genetic segregation within the resulting surface community. Our results show that the local stress distributions which arise when two microcolonies push against each other play an important role in distinguishing “winners” from “losers” – but that individual cell lag times on the surface are also a critical factor.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..