In this project, microfluidics will be used to create arrays of large numbers of monodisperse water-in-oil emulsion droplets, that can be used as picolitre containers in highly parallelized (1e4 replicates compared to 96-well plates of traditional experiments) biological physics experiments. Preliminary experiments investigating the aggregation of proteins, have suggested that the behaviour in these cell-sized containers can be very different from that observed in traditional experiments. In addition to simple protein aggregation experiments, this approach has a lot of potential in investigating how the protein capsid (shell) of a virus self-assembles, and the efficacy of antimicrobial treatments and how bacteria acquire resistance to antimicrobials.
Simple stochastic computer simulations will be used to understand and interpret our experimental results.
The project supervisors welcome informal enquiries about this project.
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The links below summarise our research in the area(s) relevant to this project:
- Find out more about Physics of Living Matter.
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