PhD project: Using microfluidics to create highly parallelized biological physics experiments

Project description

In this project, microfluidics will be used to create arrays of large numbers of monodisperse water-in-oil emulsion droplets, that can be used as picolitre containers in highly parallelized (1e4 replicates compared to 96-well plates of traditional experiments) biological physics experiments. Preliminary experiments investigating the aggregation of proteins, have suggested that the behaviour in these cell-sized containers can be very different from that observed in traditional experiments. In addition to simple protein aggregation experiments, this approach has a lot of potential in investigating how the protein capsid (shell) of a virus self-assembles, and the efficacy of antimicrobial treatments and how bacteria acquire resistance to antimicrobials.

Simple stochastic computer simulations will be used to understand and interpret our experimental results.

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