PhD project: Why and How Proteins Stick to Each Other

Project description

Ensuring that the right proteins bind to each other is a vital part of building and running healthy cells. But unwanted protein aggregation can be fatal, such as the formation of ‘amyloid fibrils’ in various neurodegenerative diseases (Alzheimer, CJD, etc.) or the clouding of the eye lens in cataracts. Preliminary work suggests that very highly charged proteins may aggregate via a new, generic mechanism. You will use a collection of physical techniques (atomic force microscopy, light scattering, gel electrophoresis, etc.) to study the mechanism of such aggregation and the structure of aggregates formed.

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