Interfacial water structure, peptide adsorption and ion-specificity
Condensed Matter lunchtime seminar
Interfacial water structure, peptide adsorption and ion-specificity
- Event time: 1:00pm
- Event date: 22nd September 2009
- Speaker: Roland Netz (Technical University Munich)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
i) Hydrophobic surfaces in contact with water show a pronounced
depletion layer
with a thickness of a few Angstroms within which the water density is
highly reduced[1].
This layer leads to unusual static and kinetic properties including a
finite slip length[2].
ii) Many polypeptides readily
adsorb on both hydrophobic and hydrophilic surfaces. Single molecule
AFM
studies yield adsorption energies and point to an extremely high
mobility on hydrophobic surfaces.
The dominant hydrophobic attraction can be quantitatively
explained with classical MD simulations including explicit water.
Both water structural effects and dispersion interactions contribute
to this solvation attraction[3].
iii) The friction coefficient of bound polymers is very low on
hydrophobic substrates, which is traced back to the presence of a
vacuum layer between substrate and water, which forms a lubricating
cushion on which a polymer can glide. Conversely, friction forces on
hydrophilic substrates are large and make determining the equilibrium
binding constant in computer simulations impossible.[4]
iv) Nominally uncharged, hydrophobic surfaces appear negatively
charged and give
rise to sizable electrostatic adsorption energies. This finding
is related to the water structure at hydrophobic substrates
which involves an oriented first water layer.
Large anions (e.g. Iodide and Bromide) adsorb more strongly than small
halides (Fluoride and Chloride) on hydrophobic surfaces,
explaining the so-called Hofmeister series that is found for
interfacial energies, surface
potentials and interactions between solutes in general[5].
v) Modeling ion specificity involves reproducing ion solvation in
water in the first
place. Some recent progress and remaining obstacles with current
Molecular
Dynamics force fields are discussed.
[1] Interfacial Water at Hydrophobic and Hydrophilic Surfaces: Depletion versus Adsorp- tion, J. Janecek and R.R. Netz, Langmuir 23, 8417 (2007)
[2] Water slippage versus contact angle: a quasi-universal relationship, D.M. Huang, C. Sendner, D. Horinek, R.R. Netz, and L. Bocquet, Physical Review Letters (2008)
[3] Peptide adsorption on a hydrophobic surface results from an interplay of solvation, surface and intrapeptide forces, D. Horinek, A. Serr, M. Geisler, T. Pirzer, U. Slotta, S. Q. Lud, J. A. Garrido, T. Scheibel, T. Hugel, R. R. Netz, PNAS 105, 2842 (2008)
[4] Polypeptide friction and adhesion on hydrophobic and hydrophilic surfaces: A molecular dynamics case study, A. Serr, D. Horinek and R.R. Netz, Journal of the American Chemical Society 130, 12408 (2008)
[5] Specific Ion Adsorption at Hydrophobic Solid Surfaces, D. Horinek and R.R. Netz Physical Review Letters 99, 226104 (2007)
[1] Interfacial Water at Hydrophobic and Hydrophilic Surfaces: Depletion versus Adsorp- tion, J. Janecek and R.R. Netz, Langmuir 23, 8417 (2007)
[2] Water slippage versus contact angle: a quasi-universal relationship, D.M. Huang, C. Sendner, D. Horinek, R.R. Netz, and L. Bocquet, Physical Review Letters (2008)
[3] Peptide adsorption on a hydrophobic surface results from an interplay of solvation, surface and intrapeptide forces, D. Horinek, A. Serr, M. Geisler, T. Pirzer, U. Slotta, S. Q. Lud, J. A. Garrido, T. Scheibel, T. Hugel, R. R. Netz, PNAS 105, 2842 (2008)
[4] Polypeptide friction and adhesion on hydrophobic and hydrophilic surfaces: A molecular dynamics case study, A. Serr, D. Horinek and R.R. Netz, Journal of the American Chemical Society 130, 12408 (2008)
[5] Specific Ion Adsorption at Hydrophobic Solid Surfaces, D. Horinek and R.R. Netz Physical Review Letters 99, 226104 (2007)
About Condensed Matter lunchtime seminars
This is a weekly series of informal talks given primarily by members of the institute of condensed matter and complex systems, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..