First passage times and nonequilibrium chromosome looping
Statistical Physics and Complexity Group meeting
First passage times and nonequilibrium chromosome looping
- Event time: 11:30am until 12:30pm
- Event date: 30th November 2016
- Speaker: Professor Davide Marenduzzo (School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
I will review the basic technique to find the mean first passage time of a stochastic process, by starting from the Fokker-Planck equation. We will then consider an application, to the formation of a chromosomal loop via a diffusing slip-link (which models cohesin, a particular kind of DNA-binding protein involved in loop formation). This problem is currently of interest due to experimental results which have uncovered some surprising features of cohesin-mediated chromosome loops.
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