Interaction between Colloids and Cells
Condensed Matter lunchtime seminar
Interaction between Colloids and Cells
- Event time: 1:00pm
- Event date: 9th February 2005
- Speaker: Didier Roux (Centre de recherche Paul Pascal CNRS Pessac France)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
In many cases the interaction between colloidal
particles and cells occurs through specific (ligands/receptors)
molecular interactions. This is typically what happens when a virus or
a synthetic vector is targeting specific sites of a cell before being
internalized.
The ligands receptors interaction has been largely studied in terms of molecular interaction (Binding constant). The case of a cell interacting with a surface through ligands/receptors interactions (adhesion) has been more recently described and important differences due to collective behaviour are expected. We show that some specificity due to colloids might be expected, which appears to be an intermediate case between ''free'' ligands and ligands bound to a surface. We present some of the differences expected through a very simple theoretical model and experiments. In particular, we show how we can measure the kinetics of adhesion of an ensemble of colloids on an ensemble of cells allowing us to calculate the energetical profile of the interaction.
The ligands receptors interaction has been largely studied in terms of molecular interaction (Binding constant). The case of a cell interacting with a surface through ligands/receptors interactions (adhesion) has been more recently described and important differences due to collective behaviour are expected. We show that some specificity due to colloids might be expected, which appears to be an intermediate case between ''free'' ligands and ligands bound to a surface. We present some of the differences expected through a very simple theoretical model and experiments. In particular, we show how we can measure the kinetics of adhesion of an ensemble of colloids on an ensemble of cells allowing us to calculate the energetical profile of the interaction.
About Condensed Matter lunchtime seminars
This is a weekly series of informal talks given primarily by members of the institute of condensed matter and complex systems, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..