Gene expression with nonlinear feedback
- Event time: 10:15am
- Event date: 11th December 2008
- Speaker: Otto Pulkkinen (University of Edinburgh)
- Location: Room 4309, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
The dynamic scenarios of gene expression with constant concentrations of active transcription factors have been thoroughly studied both theoretically and experimentally, and is now well understood. However, the stochastic dynamics is more complicated in systems with feedback, in which the gene products either directly or indirectly regulate the transcription of their own genes. Mathematical analysis of models with nonlinear feedback is particularly tricky. In this talk, we consider a class of models, the dynamics of which can be exactly characterized. The theory is applied to the lac system in E. coli and the predictions are compared with results from simulations of more detailed models.
This is a roughly weekly series of didactical blackboard talks focussing on some theoretical aspect of Condensed Matter, Biological, and Statistical Physics..