Understanding the lag phase variability of insulin fibrillation
- Event time: 1:00pm
- Event date: 15th June 2009
- Speaker: Line Jourdain (University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Conversion of misfolded protein into amyloid-like fibrillar aggregates is thought to proceed in 2 phases: slow formation of energetically unfavorable nuclei followed by subsequent rapid elongation of these nuclei. In this study, we focus on the first phase, commonly called the lag phase. In particular, we aim to determine whether the variability of the lag phase length observed for apparently identical samples could result from the inherent stochastic nature of the nucleation process as suggested by other works. To do this, we use bovine insulin as our model protein and adopt an approach that combines experiments and numerical simulations.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..