Simple Theory of Protein Folding Kinetics

Condensed Matter journal club

Simple Theory of Protein Folding Kinetics

  • Event time: 11:30am
  • Event date: 10th December 2010
  • Speaker: Katrin Wolff (Formerly School of Physics & Astronomy, University of Edinburgh)
  • Location: Room 2511,

Event details

Abstract

We present a simple model of protein folding dynamics that captures key qualitative elements recently seen in all-atom simulations. The goals of this theory are to serve as a simple formalism for gaining deeper insight into the physical properties seen in detailed simulations as well as to serve as a model to easily compare why these simulations suggest a different kinetic mechanism than previous simple models. Specifically, we find that non-native contacts play a key role in determining the mechanism, which can shift dramatically as the energetic strength of non-native interactions is changed. For protein like nonnative interactions, our model finds that the native state is a kinetic hub, connecting the strength of relevant interactions directly to the nature of folding kinetics.
PRL 105 198101 (2010)

Author

Vijay S. Pande