Protein structure prediction and folding dynamics
- Event time: 1:00pm
- Event date: 11th October 2010
- Speaker: Katrin Wolff (Formerly School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
For most proteins known today their three-dimensional structure is crucial in determining biological function. As experimental determination of protein structure is difficult and costly compared to relatively simple and cheap sequencing, it is of great practical interest to predict a protein's structure from a given amino acid sequence. Another question in the study of protein structure is how the protein folds into its biologically active (native) state overcoming free energy barriers and visiting possible intermediate states. As protein misfolding is associated with several diseases, this is of bio-medical importance, too. Moreover, folding dynamics are of fundamental interest as a mesoscopic system displaying cooperative effects. In this talk I shall attempt to give a short introduction to these two aspects of protein folding and present some results from my PhD thesis. There, so-called structural profiles were used which may act as a link between protein sequence and structure for the task of structure prediction. In protein folding dynamics they may be used to define a potential leading towards the native state.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..