Collective Cell Movements and their role in Tissue Dynamics and Morphogenesis during Development
- Event time: 1:00pm
- Event date: 3rd October 2011
- Speaker: Professor Kees Weijer (University of Dundee)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Collective cell movement is a key process during the development of many organisms. We are interested in understanding how cell-cell signalling guides and coordinates large scale cell movements and how these movement feed back on signaling to result in tissue morphogenesis. Specifically we investigate how Dictyostelium discoideum cells sue dynamics cAMP signalling to guide the movements of thousands of cells to from fruiting bodies as well as the molecular mechanisms by which cells produce and detect cAMP gradients and translate this information in directed movement up cAMP gradients. We also investigate the mode and mechanisms of collective cell movements in the chick embryo and have shown that chemo-attraction and -repulsion by growthfactor gradients are key mechanisms, but mechano-sensing and signalling also play an important role. We make extensive use of computer models explore how signalling and cell movement interact to give rise to emergent phenomena at the tissue and organism level such as pattern formation and morphogenesis.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..