Modelling Ribosome Traffic in mRNA translation: Balancing Supply and Demand
I will discuss recent work on the translation step of cellular protein production. Here, proteins are built by molecular machines called ribosomes, as they move along messenger RNAs. This process can be studied using a model similar to the totally asymmetric simple exclusion process (TASEP) with a site dependant hopping rate, but also considering the fact that ribosomes "consume" amino acids (provided by transfer RNAs) as they move. We are interested in how the gene sequence of an mRNA effects the rate of protein production. I will present results of simulations of real mRNA sequences from the yeast genome, showing how the balance between the supply and demand of different tRNAs influences protein production.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..