Emergence of motifs in model gene regulatory networks
- Event time: 1:00pm
- Event date: 2nd July 2012
- Speaker: Marcin Zagorski (Institute of Physics at Jagiellonian University)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Gene regulatory networks arise in all living cells, allowing the control of gene expression patterns. The study of their structure has revealed that certain subgraphs of interactions or "motifs" appear at anomalously high frequencies. I ask here whether this phenomenon may emerge because of the functions carried out by these networks. During this talk I will introduce the concept of gene regulation and give examples of important biological processes where interactions between genes play a crucial role. Next, the question of motif emergence will be addressed within a statistical framework which incorporates binding of gene products to DNA. By using Monte Carlo sampling with two biologically motivated functional constraints imposed on gene expression patterns, I will show that different classes of network motifs are found.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..