Coarse-grained DNA models
- Event time: 11:30am
- Event date: 9th December 2015
- Speaker: Thomas Ouldridge (Imperial College London)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
The DNA molecule is the primary information repository that underlies life's complexity. Recent years have seen two big conceptual advances. Firstly, DNA's biological role depends on its detailed biomechanical properties, rather than just the sequences of amino acids coded for by its bases. Secondly, the exquisite selectivity of DNA base-pairing has been harnessed to create rationally-designed self-assembled structures, machines and computational devices. We present a coarse-grained model, oxDNA, that is powerful enough to provide insight in both areas. We discuss recent results that explain puzzling data in stress-induced transitions, and demonstrate that oxDNA allows rational guidance of reaction kinetics for key nanotechnological processes.
This is a roughly weekly series of didactical blackboard talks focussing on some theoretical aspect of Condensed Matter, Biological, and Statistical Physics..