Brownian ratchets and chromosome loop extrusion
Statistical Physics and Complexity Group meeting
Brownian ratchets and chromosome loop extrusion
- Event time: 11:30am until 12:30pm
- Event date: 7th December 2016
- Speaker: Professor Davide Marenduzzo (School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
I will discuss the Brownian ratchet model, originally introduced by Peskin, Odell and Oster, as a framework to understand cellular motility powered by actin polymerisation. I will then present a related mechanism which we have recently come across, that involves the rectification of the diffusion of cohesin (a molecular slip-link associated with DNA) to yield extrusion of large chromosome loops.
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