A stochastic 3D polymer model of transcriptional dynamics in chromatin: variability, bursting and omnigenic effects
A stochastic 3D polymer model of transcriptional dynamics in chromatin: variability, bursting and omnigenic effects
- Event time: 11:30am until 12:30pm
- Event date: 8th May 2019
- Speaker: Professor Davide Marenduzzo (School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
The regulation of the transcriptional programme in a cell is key to its correct functioning, and underlies diverse phenomena such as development, aging, and diseases. Here we propose and study a biophysical stochastic and nonequilibrium model for transcriptional dynamics based on the binding of diffusing multivalent transcription factors to chromatin in 3D. The results show that the coupling between 3D chromatin structure and transcription naturally yields stochastic, bursty transcription, and complex gene correlation networks in the absence of any biochemical regulation. We will discuss a possible way to capture similar phenomenology with a 1D model.
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