Theoretical and Experimental Dissection of DNA Loop-Mediated Repression
Condensed Matter journal club
Theoretical and Experimental Dissection of DNA Loop-Mediated Repression
- Event time: 11:30am
- Event date: 25th January 2013
- Speaker: Dr Chris Brackley (School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
Abstract
Transcriptional networks across all domains of life feature a wide range of regulatory architectures. Theoretical models now make clear predictions about how key parameters describing those architectures modulate gene expression, and the ability to construct genetic circuits with tunable parameters enables precise tests of such models. We dissect gene regulation through DNA looping by tuning network parameters such as repressor copy number, DNA binding strengths, and loop length in both thermodynamic models and experiments. Our results help clarify the short-length mechanical properties of DNA.PRL 110 article 018101 (2013)
pdf version
Authors
James Q. Boedicker, Hernan G. Garcia, Rob Phillips
About Condensed Matter journal club
Given the diversity of research in the CM group, chosen topics vary widely. We tend to stick to high-impact journals - Nature, Science, PNAS and PRL have been popular - but this is not prescriptive..