A Single Nucleotide Resolution Model of Double Stranded DNA
We explore some of the structural, topological and mechanical features of a coarse-grained model of double stranded DNA. We validate its physical properties by measuring correlation lengths and by reproducing in silico single molecule experiments which provide an independent way of verifying the parameters of the model. Furthermore, we show that our model captures some dynamical processes of double stranded DNA such as denaturation and supercoiling. Finally, we show how this model can be extended to include base pair specificity and we discuss possible applications to other problems.
This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..