A 1D model for supercoiling-dependent transcription
A 1D model for supercoiling-dependent transcription
- Event time: 11:30am until 12:30pm
- Event date: 22nd November 2017
- Speaker: Professor Davide Marenduzzo (School of Physics & Astronomy, University of Edinburgh)
- Location: Room 2511, James Clerk Maxwell Building (JCMB) James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
During transcription, an RNA polymerase unwinds locally a double-stranded DNA, and moves on the DNA template as it reads off (transcribes) a gene. This process leads to the creation of negative supercoiling in the wake of the transcribing polymerase, and positive supercoiling ahead. This is at the basis of the "twin supercoiling domain" model of transcription which was first proposed in the 1980s. I will show an application of these ideas to a nonequilibrium 1D stochastic model of supercoiling-dependent transcription which produces bursts, absorbing states, and other nonequilibrium steady states.
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