Pseudomonas aeruginosa growth as suspended aggregates in high viscosity environment

Condensed Matter lunchtime seminar

Pseudomonas aeruginosa growth as suspended aggregates in high viscosity environment

  • Event time: 1:00pm until 2:00pm
  • Event date: 9th September 2019
  • Speaker: Dr. Yasuhiko Irie (University of Tartu)
  • Location: Room 2511,

Event details

Cystic fibrosis (CF) patients produce copious amounts of sputum in their respiratory tract that obstruct their airways. Bacterial pathogens colonise and form suspended aggregates within these thick sputa and cause chronic respiratory infections. These aggregates have long been considered to be a type of biofilm growth. However, while attachment factors such as extracellular biofilm polysaccharides are crucial for surface-associated biofilms,they are not required to develop aggregates. Therefore, suspended aggregates may represent a distinct and under-characterised growth format of bacteria. Based on our results, suspended aggregates promote multi-species microbiota by spatially restricting interspecies competition (opportunistic and common CF pathogens Pseudomonas aeruginosa + Staphylococcus aureus and P. aeruginosa + host epithelial cells). These provide intriguing framework that suggest bacterial suspended aggregate cultures may be a relevant model system relating to CF respiratory infections.

About Condensed Matter lunchtime seminars

This is a weekly series of informal talks given primarily by members of the soft condensed matter and statistical mechanics groups, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..

Find out more about Condensed Matter lunchtime seminars.