Prediction in immune repertoires: learning rules in a self-organised mess
Prediction in immune repertoires: learning rules in a self-organised mess
- Event time: 3:00pm until 4:00pm
- Event date: 10th December 2024
- Speaker: Aleksandra Walczak (Ecole Normale Supérieure, Paris)
- Location: Online - see email invite.
Event details
Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine. Can this information be used to identify a person uniquely? I will show how statistical analysis of immune repertoires sequencing experiments can answer these questions. I will then attempt to connect data to phenotypic models of evolution and show that co-evolution between immune systems and viruses in a finite-dimensional antigenic space can be described by an antigenic wave pushed forward and canalized by host-pathogen interactions. This approach allows us to see how the evolution of pathogens is constrained by selection pressures coming from immune systems.
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This is a weekly series of webinars on theoretical aspects of Condensed Matter, Biological, and Statistical Physics. It is open to anyone interested in research in these areas..
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