ICMCS Seminar - DNA Topology: Modeling Superhelically Coupled Events
ICMCS Seminar - DNA Topology: Modeling Superhelically Coupled Events
- Event time: 11:00am until 12:00pm
- Event date: 11th June 2026
- Speaker: Prof Craig J. Benham (University of California)
- Location: James Clerk Maxwell Building (JCMB) 2511 James Clerk Maxwell Building Peter Guthrie Tait Road Edinburgh EH9 3FD GB
Event details
Title: DNA Topology: Modeling Superhelically Coupled Events
Abstract: Events occurring at different positions along a DNA domain can be topologically coupled together by superhelicity. Coupled events can include transitions to non-B secondary structures and binding of ligands, proteins or complexes to the DNA. In this way the topological state of a DNA domain can affect processes by which its biological activities are regulated. In this talk I will indicate how topological coupling arises. Then I will describe an equilibrium-based approach to modeling superhelically coupled events. I will apply this approach to analyze competitions involving three transition types - from B-form to strand separation, to Z-form and to cruciforms. I will first consider how each transition type behaves in isolation, and then how they compete. Examples will be given of superhelical transitions that play roles in regulating gene expression.
Biography:
Dr. Benham received his Ph.D. in Mathematics from Princeton University in 1972. In 1976 he changed fields to mathematical biology by taking a postdoctoral position under Max Delbrück in the Biology Division at Caltech. He has authored over 100 research papers, mostly on DNA superhelicity and its influence on DNA secondary structure.
Teams (online): ICMCS seminar - DNA Topology: Modeling Superhelically Coupled Events | Meeting-Join | Microsoft Teams
About Condensed Matter seminars
This is a weekly series of informal talks given primarily by members of the institute of condensed matter and complex systems, but is also open to members of other groups and external visitors. The aim of the series is to promote discussion and learning of various topics at a level suitable to the broad background of the group. Everyone is welcome to attend..