PhD project: Force microscopy and spectroscopy of chromatin assemblies in disease
Project description
DNA stores genetic information as a one-dimensional code in all cellular life. A 1D code allows for straightforward readout and copying mechanisms, but must be very long to support the development of higher order organisms. In turn, cells face the challenge to pack the genome within their confines. For example, in every human cell 2 meters of DNA must be stored within a nucleus of approximately 5 micrometers across. This packaging problem is addressed by a hierarchy of molecular folding mechanisms, which remain poorly understood. Nevertheless, emerging evidence highlights the critical role of chromatin architecture in disease.
In this project, you will develop and use single molecule biophysical approaches (based on atomic force microscopy and magnetic tweezers), to decipher the molecular mechanisms that govern chromatin assembly. In particular, you will focus on alterations in chromatin conformations associated with disease states such as HIV/AIDS, Rett syndrome, and tumorigenesis.
The project draws on interdisciplinary collaborations within the university, as well as with international experts.
Project supervisor
- Dr Willem Vanderlinden (School of Physics & Astronomy, University of Edinburgh)
The project supervisor welcomes informal enquiries about this project.
Find out more about this research area
The links below summarise our research in the area(s) relevant to this project:
- Find out more about Physics of Living Matter.
- Find out more about the Institute for Condensed Matter and Complex Systems.
What next?
- Find out how to apply for our PhD degrees.
- Find out about fees and funding and studentship opportunities.
- View and complete the application form (on the main University website).
- Find out how to contact us for more information.